基因的mRNA序列的查找方法_如何查找基因序列
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mRNA1
Homo sapiens cytotoxic T-lymphocyte-aociated protein 4(CTLA4), transcript variant 1, mRNA
NCBI Reference Sequence: NM_005214.4
FASTA Graphics Go to: LOCUS
NM_005214
2033 bp
mRNA
linear
PRI 01-APR-2012 DEFINITION Homo sapiens cytotoxic T-lymphocyte-aociated protein 4(CTLA4),transcript variant 1, mRNA.ACCESSION
NM_005214 XM_001129541 XM_001129550 XM_001129561 VERSION
NM_005214.4 GI:339276048 KEYWORDS
.SOURCE
Homo sapiens(human)
ORGANISM Homo sapiens
Eukaryota;Metazoa;Chordata;Craniata;Vertebrata;Euteleostomi;
Mammalia;Eutheria;Euarchontoglires;Primates;Haplorrhini;
Catarrhini;Hominidae;Homo.REFERENCE(bases 1 to 2033)
AUTHORS
Ryden,A., Bolmeson,C., Jonson,C.O., Cilio,C.M.and Faresjo,M.TITLE
Low expreion and secretion of circulating soluble CTLA-4 in
peripheral blood mononuclear cells and sera from type 1 diabetic
children
JOURNAL
Diabetes Metab.Res.Rev.28(1), 84-96(2012)
PUBMED
22218756
REMARK
GeneRIF: Low protein concentrations of circulating soluble CTLA-4
and a positive correlation between soluble CTLA-4 mRNA and protein
were seen in IDDM, in parallel with a negative correlation in
healthy subjects REFERENCE(bases 1 to 2033)
AUTHORS
Rabe,H., Lundell,A.C., Anderon,K., Adlerberth,I., Wold,A.E.and
Rudin,A.TITLE
Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T
cells are aociated with lower fractions of memory CD4+ T cells in
infants
JOURNAL
J.Leukoc.Biol.90(6), 1133-1140(2011)
PUBMED
21934066
REMARK
GeneRIF: FOXP3+ or CTLA-4+ regulatory T cells may modulate CD4+ T
cell activation and homing receptor expreion in children.REFERENCE(bases 1 to 2033)
AUTHORS
Olive,D., le Thi,S., Xerri,L., Hirsch,I.and Nunes,J.A.TITLE
[The role of co-inhibitory signals driven by CTLA-4 in immune
system]
JOURNAL
Med Sci(Paris)27(10), 842-849(2011)
PUBMED
22027421
REMARK
GeneRIF: The role of CTLA4 as an inhibitory co-signaling molecule
in activated T lymphocytes is reviewed.Review.REFERENCE(bases 1 to 2033)
AUTHORS
Kimkong,I., Nakkuntod,J., Sae-Ngow,S., Snabboon,T., Avihingsanon,Y.and Hirankarn,N.TITLE
Aociation between CTLA-4 polymorphisms and the susceptibility to
systemic lupus erythematosus and Graves' disease in Thai population
JOURNAL
Asian Pac.J.Allergy Immunol.29(3), 229-235(2011)
PUBMED
22053592
REMARK
GeneRIF: No aociation between two functional polymorphisms
(+49A/G and CT60A/G)of the CTLA-4 gene and susceptibility to
systemic lupus erythematosus and Graves' disease.REFERENCE(bases 1 to 2033)
AUTHORS
Oaks,M.K., Hallett,K.M., Penwell,R.T., Stauber,E.C., Warren,S.J.and Tector,A.J.TITLE
A native soluble form of CTLA-4
JOURNAL
Cell.Immunol.201(2), 144-153(2000)
PUBMED
10831323 REFERENCE(bases 1 to 2033)
AUTHORS
Magistrelli,G., Jeannin,P., Herbault,N., Benoit De Coignac,A.,Gauchat,J.F., Bonnefoy,J.Y.and Delneste,Y.TITLE
A soluble form of CTLA-4 generated by alternative splicing is
expreed by nonstimulated human T cells
JOURNAL
Eur.J.Immunol.29(11), 3596-3602(1999)
PUBMED
10556814 REFERENCE(bases 1 to 2033)
AUTHORS
Chen,C., Gault,A., Shen,L.and Nabavi,N.TITLE
Molecular cloning and expreion of early T cell costimulatory
molecule-1 and its characterization as B7-2 molecule
JOURNAL
J.Immunol.152(10), 4929-4936(1994)
PUBMED
7513726 REFERENCE(bases 1 to 2033)
AUTHORS
Linsley,P.S., Brady,W., Urnes,M., Grosmaire,L.S., Damle,N.K.and
Ledbetter,J.A.TITLE
CTLA-4 is a second receptor for the B cell activation antigen B7
JOURNAL
J.Exp.Med.174(3), 561-569(1991)
PUBMED
1714933 REFERENCE(bases 1 to 2033)
AUTHORS
Harper,K., Balzano,C., Rouvier,E., Mattei,M.G., Luciani,M.F.and
Golstein,P.TITLE
CTLA-4 and CD28 activated lymphocyte molecules are closely related
in both mouse and human as to sequence, meage expreion, gene
structure, and chromosomal location
JOURNAL
J.Immunol.147(3), 1037-1044(1991)
PUBMED
1713603 REFERENCE(bases 1 to 2033)
AUTHORS
Dariavach,P., Mattei,M.G., Golstein,P.and Lefranc,M.P.TITLE
Human Ig superfamily CTLA-4 gene: chromosomal localization and
identity of protein sequence between murine and human CTLA-4
cytoplasmic domains
JOURNAL
Eur.J.Immunol.18(12), 1901-1905(1988)
PUBMED
3220103 COMMENT
REVIEWED REFSEQ: This record has been curated by NCBI staff.The
reference sequence was derived from AF414120.1 and AC010138.6.This sequence is a reference standard in the RefSeqGene project.On Jul 2, 2011 this sequence version replaced gi:83700229.Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene.Please see the Gene
record to acce additional publications.Summary: This gene is a member of the immunoglobulin superfamily
and encodes a protein which transmits an inhibitory signal to T
cells.The protein contains a V domain, a transmembrane domain, and
a cytoplasmic tail.Alternate transcriptional splice variants,encoding different isoforms, have been characterized.The
membrane-bound isoform functions as a homodimer interconnected by a
disulfide bond, while the soluble isoform functions as a monomer.Mutations in this gene have been aociated with insulin-dependent
diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac
disease, systemic lupus erythematosus, thyroid-aociated
orbitopathy, and other autoimmune diseases.[provided by RefSeq,Jul 2008].Transcript Variant: This variant(1)represents the longer
transcript and encodes the longer membrane-bound isoform CTLA4-TM.COMPLETENESS: complete on the 3' end.PRIMARY
REFSEQ_SPAN
PRIMARY_IDENTIFIER PRIMARY_SPAN
1-1390
AF414120.1
1-1390
1391-1398
AC010138.6
103850-103857
1399-2033
AF414120.1
1391-2025 FEATURES
Location/Qualifiers
source
1..2033
/organism=“Homo sapiens”
/mol_type=“mRNA”
/db_xref=“taxon:9606”
COMP
/chromosome=“2”
/map=“2q33”
gene
1..2033
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/note=“cytotoxic T-lymphocyte-aociated protein 4”
/db_xref=“GeneID:1493”
/db_xref=“HGNC:2505”
/db_xref=“HPRD:00474”
/db_xref=“MIM:123890”
exon
1..264
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/inference=“alignment:Splign:1.39.8”
/number=1
STS
61..1019
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/db_xref=“UniSTS:481662”
STS
125..877
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/db_xref=“UniSTS:482061”
misc_feature
126..128
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/note=“upstream in-frame stop codon”
CDS
156..827
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/note=“isoform CTLA4-TM precursor is encoded by transcript
variant 1;celiac disease 3;cytotoxic
T-lymphocyte-aociated serine esterase-4;cytotoxic
T-lymphocyte-aociated antigen 4;cytotoxic T-lymphocyte
protein 4;ligand and transmembrane spliced cytotoxic T
lymphocyte aociated antigen 4;cytotoxic T-lymphocyte
antigen 4;CD152 isoform;cytotoxic T lymphocyte
aociated antigen 4 short spliced form”
/codon_start=1
/product=“cytotoxic T-lymphocyte protein 4 isoform
CTLA4-TM precursor”
/protein_id=“NP_005205.2”
/db_xref=“GI:21361212”
/db_xref=“CCDS:CCDS2362.1”
/db_xref=“GeneID:1493”
/db_xref=“HGNC:2505”
/db_xref=“HPRD:00474”
/db_xref=“MIM:123890”
/translation=“MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPA
VVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSI
CTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDS
DFLLWILAAVSSGLFFYSFLLTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPY
FIPIN”
sig_peptide
156..260
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
mat_peptide
261..824
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/product=“cytotoxic T-lymphocyte protein 4 isoform
CTLA4-TM”
misc_feature
291..305
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/experiment=“experimental evidence, no additional details
recorded”
/note=“propagated from UniProtKB/Swi-Prot(P16410.3);
Region: Homodimerization”
misc_feature
603..620
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/experiment=“experimental evidence, no additional details
recorded”
/note=“propagated from UniProtKB/Swi-Prot(P16410.3);
Region: Homodimerization”
misc_feature
639..701
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/inference=“non-experimental evidence, no additional
details recorded”
/note=“propagated from UniProtKB/Swi-Prot(P16410.3);
transmembrane region”
misc_feature
756..758
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/experiment=“experimental evidence, no additional details
recorded”
/note=“Phosphotyrosine, by TXK;propagated from
UniProtKB/Swi-Prot(P16410.3);phosphorylation site”
exon
265..612
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/inference=“alignment:Splign:1.39.8”
/number=2
exon
613..722
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/inference=“alignment:Splign:1.39.8”
/number=3
exon
723..1975
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/inference=“alignment:Splign:1.39.8”
/number=4
STS
855..1041
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/standard_name=“STS-M37245”
/db_xref=“UniSTS:21475”
STS
1309..1436
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
/standard_name=“GDB:180415”
/db_xref=“UniSTS:48500”
polyA_signal
1951..1956
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12”
polyA_site
1975
/gene=“CTLA4”
/gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;
ICOS;IDDM12” ORIGINcttctgtgtg tgcacatgtg taatacatat ctgggatcaa agctatctat ataaagtcct
tgattctgtg tgggttcaaa cacatttcaa agcttcagga tcctgaaagg ttttgctcta
cttcctgaag acctgaacac cgctcccata aagccatggc ttgccttgga tttcagcggc
181 acaaggctca gctgaacctg gctaccagga cctggccctg cactctcctg ttttttcttc
241 tcttcatccc tgtcttctgc aaagcaatgc acgtggccca gcctgctgtg gtactggcca
301 gcagccgagg catcgccagc tttgtgtgtg agtatgcatc tccaggcaaa gccactgagg
361 tccgggtgac agtgcttcgg caggctgaca gccaggtgac tgaagtctgt gcggcaacct
421 acatgatggg gaatgagttg accttcctag atgattccat ctgcacgggc acctccagtg
481 gaaatcaagt gaacctcact atccaaggac tgagggccat ggacacggga ctctacatct
541 gcaaggtgga gctcatgtac ccaccgccat actacctggg cataggcaac ggaacccaga
601 tttatgtaat tgatccagaa ccgtgcccag attctgactt cctcctctgg atccttgcag
661 cagttagttc ggggttgttt ttttatagct ttctcctcac agctgtttct ttgagcaaaa
721 tgctaaagaa aagaagccct cttacaacag gggtctatgt gaaaatgccc ccaacagagc
781 cagaatgtga aaagcaattt cagccttatt ttattcccat caattgagaa accattatga
841 agaagagagt ccatatttca atttccaaga gctgaggcaa ttctaacttt tttgctatcc
901 agctattttt atttgtttgt gcatttgggg ggaattcatc tctctttaat ataaagttgg
961 atgcggaacc caaattacgt gtactacaat ttaaagcaaa ggagtagaaa gacagagctg
1021 ggatgtttct gtcacatcag ctccactttc agtgaaagca tcacttggga ttaatatggg
1081 gatgcagcat tatgatgtgg gtcaaggaat taagttaggg aatggcacag cccaaagaag
1141 gaaaaggcag ggagcgaggg agaagactat attgtacaca ccttatattt acgtatgaga
1201 cgtttatagc cgaaatgatc ttttcaagtt aaattttatg ccttttattt cttaaacaaa
1261 tgtatgatta catcaaggct tcaaaaatac tcacatggct atgttttagc cagtgatgct
1321 aaaggttgta ttgcatatat acatatatat atatatatat atatatatat atatatatat
1381 atatatatat atatatattt taatttgata gtattgtgca tagagccacg tatgtttttg
1441 tgtatttgtt aatggtttga atataaacac tatatggcag tgtctttcca ccttgggtcc
1501 cagggaagtt ttgtggagga gctcaggaca ctaatacacc aggtagaaca caaggtcatt
1561 tgctaactag cttggaaact ggatgaggtc atagcagtgc ttgattgcgt ggaattgtgc
1621 tgagttggtg ttgacatgtg ctttggggct tttacaccag ttcctttcaa tggtttgcaa
1681 ggaagccaca gctggtggta tctgagttga cttgacagaa cactgtcttg aagacaatgg
1741 cttactccag gagacccaca ggtatgacct tctaggaagc tccagttcga tgggcccaat
1801 tcttacaaac atgtggttaa tgccatggac agaagaaggc agcaggtggc agaatggggt
1861 gcatgaaggt ttctgaaaat taacactgct tgtgttttta actcaatatt ttccatgaaa
1921 atgcaacaac atgtataata tttttaatta aataaaaatc tgtggtggtc gttttaaaaa
1981 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
Homo sapiens cytotoxic T-lymphocyte-aociated protein 4(CTLA4), transcript variant 2, mRNA NCBI Reference Sequence: NM_001037631.2 FASTA Graphics
Go to:
LOCUS NM_001037631 1923 bp mRNA linear PRI 01-APR-2012 DEFINITION Homo sapiens cytotoxic T-lymphocyte-aociated protein 4(CTLA4), transcript variant 2, mRNA.ACCESSION NM_001037631 VERSION NM_001037631.2 GI:339276050 KEYWORDS.SOURCE Homo sapiens(human)ORGANISM Homo sapiens
Eukaryota;Metazoa;Chordata;Craniata;Vertebrata;Euteleostomi;Mammalia;Eutheria;Euarchontoglires;Primates;Haplorrhini;Catarrhini;Hominidae;Homo.REFERENCE 1(bases 1 to 1923)AUTHORS Ryden,A., Bolmeson,C., Jonson,C.O., Cilio,C.M.and Faresjo,M.TITLE Low expreion and secretion of circulating soluble CTLA-4 in peripheral blood mononuclear cells and sera from type 1 diabetic children JOURNAL Diabetes Metab.Res.Rev.28(1), 84-96(2012)PUBMED 22218756
REMARK GeneRIF: Low protein concentrations of circulating soluble CTLA-4 and a positive correlation between soluble CTLA-4 mRNA and protein were seen in IDDM, in parallel with a negative correlation in healthy subjects REFERENCE 2(bases 1 to 1923)AUTHORS Rabe,H., Lundell,A.C., Anderon,K., Adlerberth,I., Wold,A.E.and Rudin,A.TITLE Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are aociated with lower fractions of memory CD4+ T cells in infants JOURNAL J.Leukoc.Biol.90(6), 1133-1140(2011)
PUBMED 21934066
REMARK GeneRIF: FOXP3+ or CTLA-4+ regulatory T cells may modulate CD4+ T cell activation and homing receptor expreion in children.REFERENCE 3(bases 1 to 1923)AUTHORS Olive,D., le Thi,S., Xerri,L., Hirsch,I.and Nunes,J.A.TITLE [The role of co-inhibitory signals driven by CTLA-4 in immune system] JOURNAL Med Sci(Paris)27(10), 842-849(2011)PUBMED 22027421
REMARK GeneRIF: The role of CTLA4 as an inhibitory co-signaling molecule in activated T lymphocytes is reviewed.Review.REFERENCE 4(bases 1 to 1923)AUTHORS Kimkong,I., Nakkuntod,J., Sae-Ngow,S., Snabboon,T., Avihingsanon,Y.and Hirankarn,N.TITLE Aociation between CTLA-4 polymorphisms and the susceptibility to systemic lupus erythematosus and Graves' disease in Thai population JOURNAL Asian Pac.J.Allergy Immunol.29(3), 229-235(2011)PUBMED REMARK GeneRIF: No aociation between two functional polymorphisms(+49A/G and CT60A/G)of the CTLA-4 gene and susceptibility to systemic lupus erythematosus and Graves' disease.REFERENCE 5(bases 1 to 1923)AUTHORS Oaks,M.K., Hallett,K.M., Penwell,R.T., Stauber,E.C., Warren,S.J.and Tector,A.J.TITLE A native soluble form of CTLA-4 JOURNAL Cell.Immunol.201(2), 144-153(2000)PUBMED REFERENCE 6(bases 1 to 1923)AUTHORS Magistrelli,G., Jeannin,P., Herbault,N., Benoit De Coignac,A., Gauchat,J.F., Bonnefoy,J.Y.and Delneste,Y.TITLE A soluble form of CTLA-4 generated by alternative splicing is expreed by nonstimulated human T cells JOURNAL Eur.J.Immunol.29(11), 3596-3602(1999)PUBMED REFERENCE 7(bases 1 to 1923)AUTHORS Chen,C., Gault,A., Shen,L.and Nabavi,N.TITLE Molecular cloning and expreion of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule JOURNAL J.Immunol.152(10), 4929-4936(1994)PUBMED REFERENCE 8(bases 1 to 1923)AUTHORS Linsley,P.S., Brady,W., Urnes,M., Grosmaire,L.S., Damle,N.K.and Ledbetter,J.A.TITLE CTLA-4 is a second receptor for the B cell activation antigen B7 22053592
10831323
10556814
7513726
JOURNAL J.Exp.Med.174(3), 561-569(1991)PUBMED 1714933
REFERENCE 9(bases 1 to 1923)AUTHORS Harper,K., Balzano,C., Rouvier,E., Mattei,M.G., Luciani,M.F.and Golstein,P.TITLE CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, meage expreion, gene structure, and chromosomal location JOURNAL J.Immunol.147(3), 1037-1044(1991)PUBMED REFERENCE 10(bases 1 to 1923)AUTHORS Dariavach,P., Mattei,M.G., Golstein,P.and Lefranc,M.P.TITLE Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains JOURNAL Eur.J.Immunol.18(12), 1901-1905(1988)PUBMED COMMENT REVIEWED reference sequence was derived from On Jul 2, 2011 this sequence version replaced gi:
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene.Please see the Gene record to acce additional publications.Summary: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells.The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail.Alternate transcriptional splice variants, encoding different isoforms, have been characterized.The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer.Mutations in this gene have been aociated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-aociated orbitopathy, and other autoimmune diseases.[provided by RefSeq, Jul 2008].Transcript Variant: This variant(2)lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1.The encoded isoform CTLA-4delTM(also known as sCTLA4)is soluble and lacks the transmembrane domain, compared to isoform a.The exon skip represented in this variant is is based on human U90273.1, and is consistent with mouse U90270.1 and 1713603
3220103
REFSEQ: This record has been curated by NCBI staff.The AF414120.1 and AC010138.6.83700230.the data published in PMID:10831323 and PMID:10556814.CCDS Note: This CCDS representation is based on U90273.1 and on full-length RT-PCR evidence from PMIDs 10831323 and 10556814.This variant also has homology support from cow AF539438.1, mouse U90270.1 and rat U90271.1.COMPLETENESS: complete on the 3' end.PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-612 AF414120.1 1-612 613-1280 AF414120.1 723-1390 1281-1288 AC010138.6 103850-103857 1289-1923 AF414120.1 1391-2025 FEATURES Location/Qualifiers source 1..1923 /organism=“Homo sapiens” /mol_type=“mRNA” /db_xref=“taxon:9606” /chromosome=“2” /map=“2q33” gene 1..1923 /gene=“CTLA4” /gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12” /note=“cytotoxic T-lymphocyte-aociated protein 4” /db_xref=“GeneID:1493” /db_xref=“HGNC:2505” /db_xref=“MIM:123890” exon 1..264 /gene=“CTLA4” /gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12” /inference=“alignment:Splign:1.39.8” /number=1 STS 61..909 /gene=“CTLA4” /gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12” /db_xref=“UniSTS:481662” STS 125..767 /gene=“CTLA4” /gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12” /db_xref=“UniSTS:482061” misc_feature 126..128
/gene=“CTLA4” /gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12” /note=“upstream in-frame stop codon” CDS 156..680 /gene=“CTLA4” /gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12” /note=“isoform CTLA-4delTM precursor is encoded by transcript variant 2;celiac disease 3;cytotoxic T-lymphocyte-aociated serine esterase-4;cytotoxic T-lymphocyte-aociated antigen 4;cytotoxic T-lymphocyte protein 4;ligand and transmembrane spliced cytotoxic T lymphocyte aociated antigen 4;cytotoxic T-lymphocyte antigen 4;CD152 isoform;cytotoxic T lymphocyte aociated antigen 4 short spliced form” /codon_start=1 /product=“cytotoxic T-lymphocyte protein 4 isoform CTLA-4delTM precursor” /protein_id=“ /db_xref=”GI:83700231“ /db_xref=”CCDS: /db_xref=“GeneID: /db_xref=”HGNC: /db_xref=“MIM: /translation=”MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPA VVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSI CTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIAKEKKPSY NRGLCENAPNRARM“ sig_peptide /gene=”CTLA4“ /gene_synonym=”CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12“ mat_peptide /gene=”CTLA4“ /gene_synonym=”CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12“ /product=”cytotoxic T-lymphocyte protein 4 isoform CTLA-4delTM“ exon 265..612 /gene=”CTLA4“ /gene_synonym=”CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12“ /inference=”alignment:Splign:1.39.8“
NP_001032720.1” CCDS42803.1“ 1493” 2505“ 123890” 156..260 261..677
/number=2 exon 613..1865 /gene=“CTLA4” /gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12” /inference=“alignment:Splign:1.39.8” /number=4 STS 745..931 /gene=“CTLA4” /gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12” /standard_name=“STS-M37245” /db_xref=“UniSTS:21475” STS 1199..1326 /gene=“CTLA4” /gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12” /standard_name=“GDB:180415” /db_xref=“UniSTS:48500” polyA_signal 1841..1846 /gene=“CTLA4” /gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12” polyA_site 1865 /gene=“CTLA4” /gene_synonym=“CD;CD152;CELIAC3;CTLA-4;GRD4;GSE;ICOS;IDDM12” ORIGIN 1 cttctgtgtg tgcacatgtg taatacatat ctgggatcaa agctatctat ataaagtcct 61 tgattctgtg tgggttcaaa cacatttcaa agcttcagga tcctgaaagg ttttgctcta 121 cttcctgaag acctgaacac cgctcccata aagccatggc ttgccttgga tttcagcggc 181 acaaggctca gctgaacctg gctaccagga cctggccctg cactctcctg ttttttcttc 241 tcttcatccc tgtcttctgc aaagcaatgc acgtggccca gcctgctgtg gtactggcca 301 gcagccgagg catcgccagc tttgtgtgtg agtatgcatc tccaggcaaa gccactgagg 361 tccgggtgac agtgcttcgg caggctgaca gccaggtgac tgaagtctgt gcggcaacct 421 acatgatggg gaatgagttg accttcctag atgattccat ctgcacgggc acctccagtg 481 gaaatcaagt gaacctcact atccaaggac tgagggccat ggacacggga ctctacatct 541 gcaaggtgga gctcatgtac ccaccgccat actacctggg cataggcaac ggaacccaga 601 tttatgtaat tgctaaagaa aagaagccct cttacaacag gggtctatgt gaaaatgccc 661 ccaacagagc cagaatgtga aaagcaattt cagccttatt ttattcccat caattgagaa 721 accattatga agaagagagt ccatatttca atttccaaga gctgaggcaa ttctaacttt 781 tttgctatcc agctattttt atttgtttgt gcatttgggg ggaattcatc tctctttaat 841 ataaagttgg atgcggaacc caaattacgt gtactacaat ttaaagcaaa ggagtagaaa 901 gacagagctg ggatgtttct gtcacatcag ctccactttc agtgaaagca tcacttggga
961 ttaatatggg gatgcagcat tatgatgtgg gtcaaggaat taagttaggg aatggcacag 1021 cccaaagaag gaaaaggcag ggagcgaggg agaagactat attgtacaca ccttatattt 1081 acgtatgaga cgtttatagc cgaaatgatc ttttcaagtt aaattttatg ccttttattt 1141 cttaaacaaa tgtatgatta catcaaggct tcaaaaatac tcacatggct atgttttagc 1201 cagtgatgct aaaggttgta ttgcatatat acatatatat atatatatat atatatatat 1261 atatatatat atatatatat atatatattt taatttgata gtattgtgca tagagccacg 1321 tatgtttttg tgtatttgtt aatggtttga atataaacac tatatggcag tgtctttcca 1381 ccttgggtcc cagggaagtt ttgtggagga gctcaggaca ctaatacacc aggtagaaca 1441 caaggtcatt tgctaactag cttggaaact ggatgaggtc atagcagtgc ttgattgcgt 1501 ggaattgtgc tgagttggtg ttgacatgtg ctttggggct tttacaccag ttcctttcaa 1561 tggtttgcaa ggaagccaca gctggtggta tctgagttga cttgacagaa cactgtcttg 1621 aagacaatgg cttactccag gagacccaca ggtatgacct tctaggaagc tccagttcga 1681 tgggcccaat tcttacaaac atgtggttaa tgccatggac agaagaaggc agcaggtggc 1741 agaatggggt gcatgaaggt ttctgaaaat taacactgct tgtgttttta actcaatatt 1801 ttccatgaaa atgcaacaac atgtataata tttttaatta aataaaaatc tgtggtggtc 1861 gttttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1921 aaa
