土霉素的药理学研究_土霉素前景研究报告

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Pharmacological

Tetracycline antibiotics commonly used as antibiotics,by the reversible combine with the 30S ribosomal subunit, prevent Aminoacyl tRNA and ribosome binding, resulting in inhibition of protein synthesis.Some people think that tetracycline antibiotics can be combined with the 50S ribosomal subunit reversible, can also change the bacterial cell membrane permeability.At high concentrations, tetracycline antibiotics can also inhibit mammalian cells from synthesizing protein.Tetracycline antibiotics can effectively inhibit Mycoplasma, spiral body(including the Lyme), chlamydia, Rickettsia.For gram positive bacteria, tetracycline antibiotics can inhibit the Staphylococcus and Streptococcus,but the drug resistance of these bacteria enhanced.Tetracycline antibiotics antibacterial spectrum against gram positive bacteria covered include Actinomyces, anthrax bacillus, Clostridium perfringens, Clostridium tetani, Listeria monocytogenes and Nocardia bacteria.Tetracycline antibiotics uses in vitro and in vivo.Some Gram negative bacteria could also be inhibit,such as Bordetella, Brucella., Haemophilus, Pasteurella and yersinia pestis.The majority of Escherichia coli, Klebsiella pneumoniae, Bacteroides., Proteus and Pseudomonas aeruginosa is resistant to tetracycline antibiotics.Although in vitro test most of Pseudomonas aeruginosa on tetracycline antibiotic resistance, Although in vitro test most of Pseudomonas aeruginosa on tetracycline antibiotic resistance, but the high concentration in the urine of compounds(such as tetracycline, oxytetracycline)related to cure dog Pseudomonas aeruginosa secondary urinary tract infection.Oxytetracycline and tetracycline antibiotic spectrum and cro resistance to almost exactly the same.Tetracycline susceptibility test disc is usually used for drug sensitive test of Oxytetracycline.