生物专业个人陈述PS_景观专业个人陈述

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Statement of Purpose Jing Li(My application ID: 1075276;UT EID: jl49345)For Graduate Program of Cell and Molecular Biology, the University of Texas at Austin As I sat in an image proceing room of my lab, clicking away at the in situ hybridization(ISH)figures in front of me, I glanced at the mouse embryo sections one by one.They displayed the proce of mice development, the expreion pattern of Zfp521, Aqp1, AB063319, etc.in mouse embryos, and the chronological appearance of organs and tiues respectively.Was it poible that the formation of complex mammalian structures, thousands of years of evolution and the miraculous appearance of life had been encrypted into these seemingly simple images? I had to wonder: why does the development of embryos need to go through such a complex proce，rather than discarding previous forms and directly developing mammalian characteristics?

“Biology,” I answered instinctively when asked to choose my major.I was intrigued by biological phenomena as a child, and the seemingly mystical precision of it filled me with questions.Why do pandas and rabbits, similar as juveniles, grow into two very different organisms? Why are our visual experiences distinctly different from those of other organisms? Why can people talk, while orangutans, with similar anatomical configurations, can not? Being unsatisfied with any answer my parents could offer, I constantly sought relevant information from other resources.When the time came, I chose Biotechnology as my major in college without hesitation.There is a theory that the proce of mammalian development in utero replays evolutionary history: from a germ cell(like a monad), to germ layers(like coelenterate), to the appearance and disappearance of the branchial arch and tail(like in fish and amphibians), until the birth of a mammal with almost all mature organs and tiues.I wondered, why can’t mammalian traits be directly developed? Propelled by this question, I contacted one of my course instructors my freshman year, expreing the desire to enter the development lab and study this problem more actively.This instructor recommended I consult some reference books as preparation before conducting experiments independently.After more than a year of studying basic principles of experimentation in China and one year in South Korea working as an exchange student, I immediately went to the office of my current mentor, Prof.Wu.After a long talk, I succefully became one of the members of the laboratory of development at the Harbin Institute of Technology(HIT).With profeional knowledge and experimental skills acquired during the previous two years, I adapted to the specific experimental rules of the laboratory quickly.My drive and commitment to excellence proved me worthy of the position.After only two weeks, I was granted permiion to start my own project under the instruction of Prof.Wu: the identification of a novel imprinted gene and its expreion analysis in mouse embryos.Through the collaboration between my lab and a bioinformatics program at Harbin Medical University，I found several genes that were poible to be imprinted, working towards identifying a novel imprinted gene.During the proce of designing my project, I read a great deal of papers downloaded from PubMed and consulted Molecular Cloning(the third edition, J.Sambrook, D.W.Ruel)and Manipulating the Mouse Embryo(the third edition, Andras Nagy, Marina Gertsenstein, Kristina Vintersten, Richard Behringer).With the above preparation and painstaking calculation of experimental period, I selected the most suitable and efficient contents as follows.The main sections of my project include 1)identification of a specific gene’s imprinting status in seven organs(brain, tongue, heart, lung, liver, kidney and placenta)by sequencing directly, 2)performance of ISH on the slides of mouse embryos and Statement of Purpose Jing Li(My application ID: 1075276;UT EID: jl49345)For Graduate Program of Cell and Molecular Biology, the University of Texas at Austin placentas at E15.5, 3)performance of quantitative real-time RT-PCR(QRT-PCR)of this gene in seven organs, and 4)analysis of poibly influential mechanisms of the imprinting such as DNA methylation or histone modification.If needed, Northern Blotting would be performed in order to confirm the number of transcripts.As of now, I have completed all my experiments and am revising my paper to explain my findings, which I plan to publish in the near future.My operative skills and satisfactory results, as well as my commitment to meticulous scientific research have earned me the recognition of my research mentor, Prof.Wu.Last semester, I got a chance to be the teaching aistant for “Identification of Imprinted Gene and Relative Function Analysis”, a cla designed for all students including seniors, and was responsible for overseeing the student experiments.Being only a junior, I was honored by such recognition and opportunity to accept this task.During cla, I showed the method of identifying another poibly imprinted gene using a specific restriction enzyme.It also allowed me chances to utilize my communicative abilities and social skills gained from extracurricular activities, such as hosting lectures held by my union or being a teaching aistant for Michigan State University(MSU)Chinese Summer School at HIT.Aside from my project work, my stellar academic record at HIT conveyed my ability to excel in the biological sciences, and qualified me to attend a summer school of life science in University of Science and Technology of China(USTC)on full scholarship.I experienced advanced methodology from the profeors of USTC and had the opportunity to use advanced technology, such as MRI and micromanipulation.The graduate students' knowledge and skills impreed me greatly and gave me the drive to seek a Ph.D.degree.Graduate school will enable me to develop new research skills and the solid academic background that I need to become a succeful researcher.A Ph.D.program in Cell and Molecular Biology will not only cultivate and refine my interest in scientific research, but also equip me to deal with the challenges of Ph.D.programs with experimental operations in genetic, biochemistry, molecular and cellular biology, etc.I believe that I have all the neceary aets needed to be a good scientist;as far as my life’s priorities are concerned, devotion to mastery of the biological sciences is second to none.As for the future, I hope to work in academia as a researcher.I believe the University of Texas at Austin is the institution best capable of helping me reach this goal because it offers a superb method of study, streing the importance of understanding and employing different modalities of treatment.I have interest in the study of epigenetics and hope to gain a greater understanding of such topics through future doctorate studies.I plan to specialize in epigenetic regulation including DNA methylation, histone modification and their effects on gene expreion.I also recognize the value of exploring a variety of other orientations in biology, such as non-coding microRNA regulation in development, environmentally-induced epigenetic change, stem cell biology, etc.As the University of Texas at Austin also allows students to complete research rotations in at least three different faculty laboratories in their first year, it offers me several opportunities from which to choose, making the University of Texas at Austin an even more ideal school for me.