制药工程专业《文献检索与专业外语》试卷_文献检索试卷及答案
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10-11学年下半年《文献检索与专业外语》期中考试
姓名：学号：专业：成绩：
一、英译汉（30）
Abstract : The proce of complex coacervation encapsulation for oil core materials was studied.Bean oil was selected as the core material and the gelatin and Arabic gum as coating materials.The factors that affect the proce , such as pH value , reaction temperature , reaction time , reaction concent ration and stirring speed , were investigated.The results showed that the optimal conditions were as follows: emulsifying 2 % of Arabic gum and 2 % of gelatin , condensing at pH 4.0～4.5 for 15～20 min , stirring with a speed of 1500 r/ min , and solidifying at 10 ℃ for 60 min.The stirring speed exerted an important influence on the appearance and particle size distribution of the products.Key words : microcapsule;complex coacervation;gelatin;Arabic gum
二、汉译英（40）
摘 要：“制药工程设计”面临的都是真实、复杂的实际工程问题，如何将车间设计与制剂技术、GMP、设备及公用工程有机地组合在一起进行研究与教学已成为制药工程专业教学与科研的当务之急。文章针对各教学环节的特点，结合教学实践，围绕着教学内容和教法，介绍了为提高教学效果所做的课程教改实践与尝试，具体措施包括：激发学习兴趣、理论联系实际、加强课程设计考核、提高实习效果等，阐述在制药工程设计的教学中该如何培养学生的工程素质，使学生能将理论知识与工程实际衔接起来，逐步实现由学生向制药工程师的转变。关键词：制药工程设计；工程素质；实践；教学改革
三、阅读以下短文，综述短文摘要（200字，30）
Microcapsules are used in various applications, such as pharmaceuticals, food additives, coatings, electronic inks, catalysts, dyes, etc.The microencapsulated self-healing agents applied to polymeric composites is also one of the new options for microcapsule applications.Microcapsules are prepared by various chemical and physical methods.One of the microencapsulation methods most often used is the phase separation method with amino resins such as urea and melamine, which form the capsule wall by condensation polymerization with formaldehyde.The formation of urea–formaldehyde capsules has been described by many authors.The proce consists of the reaction of urea and formaldehyde to obtain methylol urea, which further condenses under acidic conditions to form the shell material.In order to control the morphology and to prepare the microcapsules having the desired physical properties, it is neceary to know the wall-forming mechanism.The paramount objective of this study is the clarification of the wall formation
mechanism of the polyurea microcapsules by the phase separation method.In general encapsulation proce, core material is emulsified for the formation of core drops in the previous stage and the drops obtained are covered by wall material in the succeeding stage to complete the microcapsules.However, it is usually very difficult to control the drop size of core material in the first stage of emulsion and to obtain drops with a favorable size and narrow size distribution.Furthermore, this mean size and size distribution, which are mainly determined by the first emulsification, would influence the following capsulation proce.So it is remarkably difficult to understand the true encapsulation mechanism in the second microencapsulation stage separated from the first emulsification.To solve this problem, Kage et al.succefully investigated the microencapsulation mechanism of the complex coacervation method by completely excluding the complicated effect of the first emulsification.In their study, gla beads with a narrow size distribution were adopted as a solid core in order to obtain uniform core size.A similar approach was adopted in this research and spherical gla beads with a narrow size distribution were encapsulated by urea–formaldehyde by in situ polymerization.By the choice of gla bead as a core, the surface treatment for gla would have significant effects on how the polymer forms on and bonds to the gla.Even more fundamentally, the surface treatment will affect how much water the gla takes up from both ambient humidity and the aqueous bath, which could affect the surface state of the gla bead.Kage et al.discued the core surface state on the microencapsulation by treating the surface with dimethyldichlorosilane.In this study, the gla beads surface was treated to hydrophobic with the method mentioned above and then used as cores.Factors determining the microencapsulability of the core material were investigated.In particular, our interest was devoted to better understand the influence of reaction parameters on the microcapsule properties.
